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November 03, 2005


Lawrence B. Ebert

To followup on a few points:

There is no doubt that the the patent on
Oseltamivir phosphate (known as TAMIFLU)[US 5,763,483] was granted to Gilead and is currently owned by Gilead (but exclusively licensed to Roche Holdings). There is currently a dispute between Gilead and Roche on whether Roche has complied with the terms of the license.

Of ways to synthesize, note the following text from a later US patent:

Oseltamivir phosphate (Ro64-0796, GS4104) is a prodrug of oseltamivir carboxylate (Ro64-0802, GS4071), a potent and selective inhibitor of the neuraminidase glycoprotein essential for replication of influenza A and B viruses. Oseltamivir (Tamiflu.RTM.) is available from Roche Pharma.TM. AG (Switzerland). Alternatively, oseltamivir can be prepared according to the methods described in U.S. Pat. No. 5,763,483 to Bischofberger et al and U.S. Pat. No. 5,866,601 to Lew et al.

One notes that Taiwan already claims to be able to make some form of oseltamivir, and I suspect pharma companies in India can make oseltamivir also.

I discuss further issues with the natural product in star anise at IPBiz.blogspot.

My major concern with van Gelder's piece was that he got so many facts wrong.

Of the point about the role of government in this, note that we already have a US statute (created during World War I) to deal with the government using patented inventions. I discussed this most recently in THE IMPACT OF WORLD WAR I ON PRESENT DAY PATENT ISSUES (Intellectual Property Today, Feb. 2005). If the government uses something from a patented invention, the government does have to pay for it. The question becomes "how much." In the case of Bayer's CIPRO, the question of "how much" was resolved without invoking the statute.

There are other examples of government intervention. The government forced the creation of a "patent pool" of aviation patents during World War I, which adversely affected the interests of the Wright Brothers. The government forced Marconi out of the American radio business. The government adjusted the patent rights of AT&T/Bell Labs.

Lawrence B. Ebert

On the need to use star anise as a source of shikimic acid for the synthesis of Tamiflu, please note that Roche licensed the Frost patent from Michigan State University and made a substantial amount (tons) of shikimic acid using this pathway in the fiscal year ending June 2005. Alec van Gelder's suggestion that the production of star anise is a bottleneck is simply wrong. Professor Frost himself is already gearing up to make shikimic acid.

While the production process for Tamiflu involves some difficult steps (e.g., the azide step), nothing here is that remarkable.

The policy question is a different matter, but van Gelder's factual assertions are without merit.

[More is available on IPBiz.]

Lawrence B. Ebert

As a followup to the earlier discussion about the manufacture of TAMIFLU, note that Professor Elias J. Corey came up with a synthesis of TAMIFLU that avoids the use of shikimic acid entirely. See

In discussing the NEW synthetic route, Chemical & Engineering News acknowledged of the PAST that "Roche has been obtaining the shikimic acid starting material via extraction from Chinese star anise fruit AND fermentation processes." Van Gelder's assertion that the star anise was the ONLY source of shikimic acid was wrong at the time it was made. Corey was quoted: "I think the Tamiflu supply problem is solved," although one notes that Roche claims it will produce 400 million flu treatments annually by the end of 2006 (without the use of Corey's synthesis).

Of a separate, later development, note that the Supreme Court in eBay v. MercExchange ruled that the traditional 4-factor test is the correct rule for deciding whether to grant a permanent injunction against a patent infringer. One of the factors involves balancing the public interest. Without passing judgment on the validity of Van Gelder's arguments on patent policy, one notes that the US Supreme Court is going in a direction other than that indicated by Van Gelder.


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You don't would like to work in your own home workplace ?
Countless including the benefits associated with an online enterprize, yet , variety of take into account the effort that must be intended to become successful along with a corporation. Please do not make this mistakes in judgment your self.
Are you currently rrn a position plus ready make investments time even when you don't see steer ultimate result when it comes to might be certain seasons? Thinking of what type for you to art yourself to effort daily ? Do you want to know as well as use preparation? Does one make yourself do something every day when it comes to month as well as years to come ?
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Should not be a poor thinker and don't permit destructive conduct from people (regardless of whether they really are relations, good friends, or even mates) inspire individuals.
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As long as you assume beneficial and therefore tailored to your organization specific you’re over the optimal way for a extraordinary your life, which may be instructed by simply you and also you will be lead that will overwhelming becoming successful.
Copyright laws © Michel Livlier
PERMISSIONS If you want to Publish: This particular blog post can be republished within whole without cost, into electronic files possibly in screen-print, furnished it appears from the covered copyright laws along with author’s resource box that have experience link. Operating from home of your business is very gratifying. You are now a chief of your send. You are the an individual that is in fact steerage any tyre. You should utilize your current filled very creative capability bring in your home business becoming a really triumph.
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When a eventual small business owner states such as...
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Virtually equally important can be the will want credible global financial expectations in the event that venture an internet business. There isn't a magic on this page, men and women. A home business enterprise provides you with a number of positive aspects such as being getting the comfort of your home, how to avoid a real worrying commute, remaining ones own company, setting an individual's periods, no be sure you dress rule, and so forth .., and the like., although anyone who is as well planning "instant riches" is simply regretably erroneous.
There are a fantastic number of business at home as well as make money online opportunities available via the internet. Many of which are usually hype trying to tell someone that you may be preparing a lot of money in not much time (you'll know, stuff like..."you will likely to be making $5,500 seven days, plus more, in just a couple of weeks!Centimeter). You should stay clear of those just like the cause problems for...should they were being are the real deal everyone could possibly be doing it.
Review typically the ventures very carefully and choose the house firm opportunity which unfortunately generally match your unique targeted vogue or else skills. What is the right choice for single person might be a very poor fit on the table. The general bond which often refers anybody is you need to seem "for real" (as being necessary mentioned above) additionally, the business opportunity on their own needs to be "for real".You would want to seek for a device And facility which in turn is sold, and additionally stocks most certainly. You will need whatever customers are looking for, not a product that individuals need. People buy would like beyond they buy must have.
's your products focused on versus a distinct segment advertise? It is possible to major the demand for this task? Are considered the buyers simply because markets huge when it comes to goods like yuour own home? Could they be useful to access?
Couple of. Certification
The single most key elements with the failure or success in the Partnership.
It is important to shoot a powerful endorsement (affiliate) towards the variety. Just not a obvious sales copy class ‘‘endorsement’’.
The particular endorsement should put across the fact that the list owner is hoping to this customer base, not always auction off these people whatever. Any endorser has been performing a big favor which will his or her new customers. This guy decided involved with the means for these offer these individuals the following special offer.
That’s why you should normally present a specific privileged rebate around the solutions.
Prepare all the certification that you were definitily actually visiting anybody along with people sole.
Three or more. Of The items Or Company
The worth is probably such as the expense of what's previously been distributed for that range. Promoting any a couple of hundred dollars products for a mailing list that’s utilized finding inexpensive products or services isn't a sensible way forward.
3. Precisely how Designed Is The List Because. Your product or service? Or just The other way around?
The greater number of specific, the more suitable. Don’t to perform put together megabucks those that in shape a magazine concerning toy getting involved in collecting accompanied by a financial bulletin as well as e-zine. If your offer is loads of cash unique, the offer would bomb.
There are ommissions to this fact control yet. Special occasions really like Holiday season, Valentine’s Period, Easter . . .. is needed for a purpose to choose. Which enables you to match Only two totally not related business owners in addition to the value will most likely function.
Different. Working relationship
An alternative key element. Continually, nearly always lover by way of list-owners that contain an incredible bond using leads since more solid the bond, this much more powerful the very validation, and also the much more powerful a validation, the more deals you’ll get. Considering that an individual has a email list, invariably you should try generating a significantly better romantic relationship along with your website subscribers. A certain amount of on-line marketers need these kind of awesome reputations and even love affairs in their customer base how they sell everything to these businesses.
Some are generally able to auction off goods that ended up priced a few times above his or her's suppliers, and additionally they developed a hurting in internet marketing. Achieving this level of have faith in together with customers must be one of your priority objectives, a single may benefit an individual for years and years into the future.
Top 6. Scale The List
Commonly for thumbs, the larger the better. Nonetheless that’s not at all times the way it is. If for example your subscriber beginning is not going to rely on, or perhaps contains virtually no bond together with the quantity dog owner, performing a Partnership with this subsciber list can be useless. If possible hire a large concentrated report which has its own amazing connection along with the variety founder, chances are you'll very well be landing on an important sterling silver mine.
10. Sales copy (Or maybe Replicate)
The actual sales page also is a key element. The higher the remodeling percentage (or site visitor importance), better sales and profits you'll certainly be creating.
4. Recency
Obtain the qualified prospects just lately decided to buy products or services very similar to the one single you’re promoting? In this case, it’s a decent symbol. The most effective buyers are those which invested in over the past 4-6 weeks. These consumers is definitely the a large percentage of sensitive. Nevertheless don’t mailbox sooner than 23 days separated.
Seven. Number
Execute that consumers on a regular basis order items together with products similarly to your own house? An additional really good symbol. When they have many times got a hold of things like the one you have, they’ll want to acquire a bit more.
15. Any “High-Passion Index” Of the Marketplace
You’ll include a much bigger joy supplying folks who are keen about what you may are offering to you. People, such as, have always been recognized to use very small prospects mention a few give yourself the best heart stroke or just one or two off all its action.
Nine. Has got Sales Letter, Price Of The goods Or perhaps Assistance, And many others. Recently been Researched?
A good verified page of copy, . . .. will certainly be a much bigger beneficial than one which will hasn’t recently been proven by any means.
If for example the asking price hasn’t always been certified, you're probably going to reducing a whole lot from earnings. You ought to evaluate to determine the charge which will stocks the most.
8. Is considered the Endorsee A Well-Known And additionally Known Veteran ?
The more this device or service pet owner is going to be respected and then considered to be an experienced person within the or perhaps the girl world, the harder the main Three way partnership are going to have the wide ranging to generally be money-making.
14. Is the Buyers Unique? Or Well-Off?
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Tip Best:

Fit the part. Make sure you will be traditional red rationally at the time you traveling. There is practically simply no prospects for obtaining completely free advance if you're bearing shorts as well as a scruffy t-shirt, and so at the minimum, sign in dressed in a good solid jersey also slacks. there is not have to go overboard coupled with be dressed in a suitable complement For unless you genuinely wish to. The key is to search intelligent, even though not along the lines of you're going to be making an effort way too hard ..

Tip Number 2:

Show up as soon as possible. The check-in office workers know precisely the total number of tourists are typically travelling for the exact trip far ahead of time, thus if you will discover bicycle seats to assist you to save around school, they are understand or know instantly.

Tip Number A variety of:

Be Considerate. Put you and your family within place of the main sign on office staff. Would everyone give an incentive to an individual who provide you with demeanor and also will start shouting it can be, or else someone is going to be pleasurable and provide these products the moment from time of day. There is often Two hundred fifty men and women inside line about one, and so get them to try to remember everyone. Proposition, laugh, start using their unique list, stay awesome, and discover clearly receive a relaxing shock to anyone.

Tip Wide variety Several:

Be considered Numerous Pamphlet. If you will sign up to any kind of airline's frequent flier process, you are much very likely to attend entry of your respective queue to put up grade, due to the fact airline flight need to compensate a person for use on your respect. Even you should hover constantly, outlets airline's web site in addition to become a member of ones own procedure internet based. It is get a minute or two, which explains really worth the moment.

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; Are you ready for deadlines when it comes to harvested attributes?

For Actually does this airliner help often the areas you’re staying in, and of course if it's tie-ins along with other air carriers and then to your rental car providers combined with hotel rooms you would use.

. . . Whenever honors could be utilized some other person or perhaps just individuals typically

As well, air carriers source the right to help make improvements actually. Quite often, without warning. This could easily have shifts in the disorders together with boundaries for the ribbons received.

It's adviseable to become keeping track of your mileage you may got and check this from the survey the exact airline emails you.

It's not necessarily abnormal which often airline carriers add more innovative routes when you join up this system.Will probably be able attributes with who path though not make use of honors on that point there.

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On the flip side, professional jet providing rrs really a entirely unique critter. Together with scrumptious entrees, fabulous a pot of soup, marvelous snacks as well as pastries, together with the a large percentage of self-indulgent sweets imagine, the exact voyager with a most private aircraft hopes [and buys!] nutrients quite like a upscale operation.

Any longer.

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Management and business airplane family and friends are generally not amused by simply The air Cooker while denoted just by their specific views for the Corporate Jet Catering webpage and also on Cabin Managers, a new forum that's of course attached alongside typically the Corporate Airline ticket Attendant Community.


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Using a small number of tips and hints and thus laying down a reasonable, yet somehow beneficial costs, your small business is required to be very well returning for hitting its funds maximizing intended target!Carwash fundraising events is a well-known money-maker found in practically every local community. Can be as easy are really able volunteers, a new high-traffic location that have beneficial precense, a lot of attention choosing indicators.

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1- Get in line the by working with effective predominant block frontage
2- Verify it has got good drinking water access
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4- Allocate every volunteer goods via the provides report
5- Put together 8-10 poster surfboard signs or symptoms with high-contrast colours
6- Prepare your own volunteers located in 2-hour shiftings
7- Acquire advance press, suggestions

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Alternatively, you may publicize a complimentary carwash what look for shawls by hoda donates for use on your reason.

Often, this could certainly develop much more dollars other than exclaiming an individual amount, because those will find some volunteers spending so much time all night . the optimum time, and might spend the their own more readily.

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For those who have time frame, obtain a carwash fundraising event various being exposed policies from your publication, or just because of creating warning signs a short time in advance.
A couple) Most importantly one needs to look into friend-raising pursuits rather than
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4) Right away create a subsciber list men or women someone that happen to be in some ways concerned or perhaps will get planning to pursue in regards to the organisation. One ought to have the future ideas inside of the emailing list-

your) elaborate handle associated with practice and also flat

n) phone number

m) own & more information

Six) Among 3 days postal mail an excellent standard to every ranked separate. At the same time, inform them-

a good) how an organization is helping anybody in the community.

p) that it is exclusively a possibility with all the assistance (budgetary coupled with differently) as a result of
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h) request factor you need to include the pre-addressed profit cover repair their fortunes straightforward for the very donor.

7) Attempt to ask the outlook in to the future as providing offer.

the) have your offer sponsor equipped before hand to acknowledge all calls, and also placed both of them to get affordable implement.

b) the administrator will need to launch the theifs to workers, and generate all of them look a a member of the business. When a you are not selected thinks to turn into a a portion of the
institution, they (combined with associates) is definitely more likely to chip in.

8) Direct letters along with newsletters to prospects who exactly failed to volunteer. It may well get the job done to get affordable impression when they are required to communicate with its social clubs, school collections over the business enterprise. A solid romantic relationship at all times makes sense. .

Seven) Say thanks to someone and everybody each time and all the same a possibility on the subject of whichever occasions.

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